Familial hyperlipidemia is defined by abnormal levels of the following: low density lipoprotein cholesterol (LDL-C); high density lipoprotein cholesterol (HDL); triglycerides (TAG); or any combination of the three. Furthermore, while the disease is of a polygenic nature and at current time is poorly understood, it has been noted that the proteins apoB (needed for the LDL receptor and to aid in the removal of LDL from circulation) and apoE (which aids in the clearance of chylomicrons and very low density lipoprotein) present abnormalities in this illness [1]. With respect to apoB abnormalities, a Mendelian inheritance pattern has been observed in a number of cases despite the fact that familial hyperlipidemia is determined by interaction of multiple genes [2,3] and occurs in only 1-2% of the general population [4].
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