Low PD-1 expression and no prognostic impact in early-stage Mycosis Fungoides: 61 patients retrospective cohort analysis

Gustavo Moreira Amorim1,2,3*, Danielle Carvalho Quintella1, João Paulo Niemeyer Corbellini1, Luiz Claudio Ferreira4, Marcia Ramos-e-Silva1,2 and Tullia Cuzzi1,2,4

Background: Mycosis fungoides (MF) is an indolent behavior cutaneous T-cell lymphoma. Most patients present a slowly progressive course, over many years. However, some patients evolve early towards advanced stages of the disease, despite adequate treatment, having therefore, a worse prognosis. Increasing knowledge of risk factors that contribute to a better prognostic evaluation is considered of interest.

Aims: Evaluate positivity and prognostic importance of PD-1 marker in early-stage MF.

Methods: Retrospective cohort study with early-stage MF patients. Cases were defi ned by Pimpinelli criteria. PD-1 positivity was tested in complementary immunohistochemistry over the fi rst skin biopsies done in our hospital. Disease progression, death and MF-related death was investigated 5 years after the date of the diagnostic defi nition according to the proposed criteria. The hazard ratio was calculated as association measurement. Adopted signifi cance criterion was 5%.

Keywords:

Published on: Jul 20, 2019 Pages: 12-17

Full Text PDF Full Text HTML DOI: 10.17352/2455-8605.000032
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